Clinical studies
BOREAL study
Inclusion center: 8 centers in France
Validation of BVS performance3,
algorithms for early detection of COPD exacerbations

e-MEUSE study
Inclusion center: CH Verdun
Benefits of Bora care® on the quality of life of COPD patients
Post-market study

DACRE study
Inclusion centers: 4 in Brittany
Validation of biomarkers of COPD exacerbations and
retrospective validation of algorithms
for predicting COPD exacerbations
Pre-marketing study

Clinical validations
BIOSENCY BORA Band vs Reference CO-Oximetry
Non-motion, 10 Subjects, February 19-21, 2019

BIOSENCY Bora Band Respiratory Rate vs Reterence End Tidal
Carbon Dioxide Respiratory Rate
20 Subjects, 26 June 2019 – 23 July 2019

On the Accuracy of Phase Extraction from a Known-Frequency Noisy Sinusoidal Signal
APSIPA Transactions on Signal and Information Processing
Authors: Dervieux E., Tilquin F., Bisiaux A., Uhring W.
Date : October 2024
AECOPD prediction through a remote monitoring system
European Respiratory Journal 2024; 64(suppl 68): PA378
Authors: Tilquin F., The Liepvre S., Le Guillou Y., Balbolia S., Cornu JC, Estève V., Joyeux-Faure M., Pépin JL
Date : September 2024
Dual Lifetime Referencing for Accurate CO2 Sensing: An Experimental in vitro Validation
2024 IEEE 22nd Interregional NEWCAS Conference
Authors: Dervieux E, Uhring W.
Date : June 2024
Use of vital signs remote monitoring for long-term oxygen therapy adjustment: results from the APOR multicenter study
Respiratory Diseases Review News Volume 16, Issue 1, January 2024, Page 76
Authors: Le Liepvre S., Brechoir, Mangwa CL, Balbolia S., Coiffey M., Bakébé A., Le Guillou F., Droneau S., Courtaillac C., Hardy S., Alfandary D., Cornu JC, Cavailles A.
Date : January 2024
Skin temperature influence on transcutaneous carbon dioxide (CO2) conductivity and skin blood flow in healthy human subjects at the arm and wrist
Journal Frontiers in Physiology, Physio-logging section
Authors: Dervieux E., Théron M., Guerrero, F. Uhring W., Giroux-Metgès MA
Date : December 2023
Preventing hospital readmissions of COPD patients: alerting rules on vital signs for remote patient monitoring
European Respiratory Journal 2023, 62: PA3780
Authors: Tilquin F., The Liepvre S., The Guillou Y., Brinchault G., Guy T., Thepault F.
Date : September 2023
Vital Signs Remote Patient Monitoring in Real-life for Early Detection of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine 2023, 207:A4496
Authors: Le Guillou Y., Tilquin F., The Liepvre S., Bisiaux A., Cornu JC, Laurent S., Estève V., Pépin JL, Joyeux-Faure M, Dron JC
Date : May 2023
Real-life vital sign changes in COPD patients: preventive factors for readmission after hospitalization for severe exacerbation - DACRE real-life clinical study
Respiratory Diseases Reviews, vo.15, issue 1, p 70, Jan. 2023
Authors: Brinchault G., Guy T., Thepault F., The Liepvre S., Vuorinen A., The Guillou Y., Tilquin F.
Date : January 2023
Validity of Ultra-Short-Term HRV Analysis Using PPG
Sensors 2022, 22(20), 7995
Authors: Taoum A, Bisiaux A., Tilquin F., Le Guillou Y., Carrault G.
Date : October 2022
Integrated management of chronic respiratory diseases: a real-life clinical study eMeuse Santé.
Respiratory Diseases Reviews, vo.14, issue 1, p 151, Jan. 2022
Authors: Pepin JL, Joyeux-Faure M., Cornu JC, Amrani K., Haan P., Grillier, The Guillou Y., Esteve V., Dron JC, Kozasey S., Cimino A.
Date : January 2022
Personalised and integrated management of severe COPD patients at home combining remote monitoring of vital signs and therapeutic education.
Revues des Maladies Respiratoires, vo.14, issue 1, p 178, Jan. 2022
Authors: Cornu JC, Laurent S., Estève V., Martinez C, Le Guillou Y., Dron JC
Date : January 2022
Carbon Dioxide Sensing — Biomedical Applications to Human Subjects
Sensors 2022, 22(1), 188
Authors: Dervieux E., Uhring W., Théron M.
Date : December 2021
Clinical grade SpO2 prediction through semi-supervised learning
IEEE 20th international conference on BioInformatics and BioEngineering (BIBE)
Authors: Priem G., Martinez C., Bodinier Q., Carrault G.
Date : October 2020
Measuring hemoglobin spectra: searching for carbamino-hemoglobin
Journal of Biomedical Optics
Authors: Dervieux E., Bodinier Q., Uhring W., Théron M.
Date : October 2020
Poster presented by Soumaya Balbolia at the CPLF 2024 congress.
Le Liepvre S.; Brechoire I.; Mangwa CL; Balbolia S.; Coiffey M.; Bakébé A.; Le Guillou F.; Droneau S.;
Courtaillac C.; Hardy S.; Alfandary D.; Cornu JC; Cavailles A. Usefulness of remote monitoring of vital signs for the adaptation of long-term oxygen therapy: Results of the APOR multicenter study

Poster presented by Yann Le Guillou at the American Thoracic Society International Conference (ATS 2023)
Y. Le Guillou, F. Tilquin, S. Le Liepvre, A. Bisiaux, JC Cornu, V. Estève, JL Pépin, M. Joyeux-Faure, JCDron, Vital Signs Remote Patient Monitoring In Real-life For Early Detection Of AECOPD

Poster presented by Dr. Brinchault G. at the CPLF 2023 congress.
Brinchault G., Guy T., Thepault F., Le Liepvre S.*, Vuorinen A., Le Guillou Y., Tilquin F., Real-life evolution of vital signs in COPD patients: preventive factors for readmission after hospitalization for severe exacerbation – DACRE real-life clinical study.

Poster presented by Dr JC Cornu during the CPLF 2022 congress.
JC Cornu, S. Laurent, V. Estève, C. Martinez, Y. Le Guillou, JC Dron, Personalized and integrated management of severe COPD patients at home combining remote monitoring of vital signs and therapeutic education, Revue des Maladies Respiratoires News , Volume 14, Issue 1, 2022, Page 178, ISSN 1877-1203, https://doi.org/10.1016/j.rmra.2021.11.306.
