Clinical studies

BOREAL study

Inclusion center: 8 centers in France
Validation of BVS performance3
algorithms for early detection of COPD exacerbations


e-MEUSE study

Inclusion center: CH Verdun
Benefits of Bora care® on the quality of life of COPD patients
Post-market study


DACRE study

Inclusion centers: 4 in Brittany
Validation of biomarkers of COPD exacerbations and
retrospective validation of algorithms
for predicting COPD exacerbations
Pre-marketing study

Clinical validations

BIOSENCY BORA Band vs Reference CO-Oximetry
Non-motion, 10 Subjects, February 19-21, 2019


BIOSENCY Bora Band Respiratory Rate vs Reterence End Tidal
Carbon Dioxide Respiratory Rate
20 Subjects, 26 June 2019 – 23 July 2019

Frontiers in Physiology – Volume 14

Skin temperature influence on transcutaneous carbon dioxide (CO2) conductivity and skin blood flow in healthy human subjects at the arm and wrist

Authors: Emmanuel Dervieux, François Guerrero, Wilfried Uhring, Marie-Agnès Giroux-Metgès, Michaël Théron

Date : January 2024

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American Journal of Respiratory and Critical Care Medicine 2023, 207:A4496

Vital Signs Remote Patient Monitoring in Real-life for Early Detection of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Authors: Yann Le Guillou, Florian Tilquin, Sylvain Le Liepvre, Alexis Bisiaux, Jean-Claude Cornu, Sabine Laurent, Valérie Estève, Jean Louis Pépin, Marie Joyeux-Faure and Jean Charles Dron

Date : January 2023

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Journal Sensors MDPI Sensors 2022, 22(20) 

Validity of Ultra-Short-Term HRV Analysis Using PPG

Authors: Aline Taoum, Alexis Biseaux, Florian Tilquin, Yann Le Guillou, and Guy Carrault

Date : October 2022

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Revues des Maladies Respiratoires, vol.14, issue 1, p 178, Jan. 2022 – Personalized and integrated care for severe COPD patients at home combining remote monitoring of vital signs and therapeutic education.

Authors: Jean-Claude Cornu, Sabine Laurent, Valérie Estève, Coralie Martinez, Yann Le Guillou, Jean-Charles Dron

Date : January 2022

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Sensors 2022, 22, 188. – Carbon Dioxide Sensing — Biomedical Applications to Human Subjects

Authors: Emmanuel Dervieux, Wilfried Uhring, Michaël Théron

Date : December 2021

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IEE 20th international conference on BioInformatics and BioEngineering (BIBE) – Clinical grade SpO2 prediction through semi-supervised learning

Authors: Gurvan Priem, Coralie Martinez, Quentin Bodinier, Guy Carrault

Date : October 2020

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Journal of Biomedical Optics – Measuring hemoglobin spectra: searching for carbamino-hemoglobin

Authors: Emmanuel Dervieux, Quentin Bodinier, Wilfried Uhring, Michaël Théron

Date : October 2020

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Poster presented by Soumaya Balbolia at the CPLF 2024 congress.


Le Liepvre S.; Brechoire I.; Mangwa CL; Balbolia S.; Coiffey M.; Bakébé A.; Le Guillou F.; Droneau S.;
Courtaillac C.; Hardy S.; Alfandary D.; Horned JCB; Cavailles A. Usefulness of remote monitoring of vital signs for the adaptation of long-term oxygen therapy: Results of the APOR multicenter study

Poster presented by Florian Tilquin at the ERS 2023 congress.


Y. Le Guillou, F. Tilquin, S. Le Liepvre, G. Brinchault, T. Guy, F. Thépault – Preventing COPD patient hospital readmissions: alerting rules
on vital signs for remote patient monitoring

Poster presented by Yann Le Guillou at the American Thoracic Society International Conference (ATS 2023)


Y. Le Guillou, F. Tilquin, S. Le Liepvre, A. Bisiaux, JC Cornu, V. Estève, JL Pépin, M. Joyeux-Faure, JCDron, Vital Signs Remote Patient Monitoring In Real-life For Early Detection Of AECOPD

Poster presented by Dr. Brinchault G. at the CPLF 2023 congress.


Brinchault G., Guy T., Thepault F., Le Liepvre S.*, Vuorinen A., Le Guillou Y., Tilquin F., Real-life evolution of vital signs in COPD patients: preventive factors for readmission after hospitalization for severe exacerbation – DACRE real-life clinical study.

Poster presented by Dr JC Cornu during the CPLF 2022 congress.


JC Cornu, S. Laurent, V. Estève, C. Martinez, Y. Le Guillou, JC Dron, Personalized and integrated management of severe COPD patients at home combining remote monitoring of vital signs and therapeutic education, Revue des Maladies Respiratoires News , Volume 14, Issue 1, 2022, Page 178, ISSN 1877-1203, https://doi.org/10.1016/j.rmra.2021.11.306.